Modulim’s patented spatial frequency domain imaging (SFDI) technology is useful in applications where clinicians need timely, accurate, noninvasive, quantitative assessment of oxygen availability, extraction, and saturation.


Diabetic foot ulcers


Our goal is to help clinicians reduce the number and severity of diabetic foot ulcers (DFUs). Despite the advancement in treatment and technology, DFUs are still common, costly, and debilitating. Poor peripheral circulation can promote the onset of a DFU, which is difficult to heal and often leads to amputation. To facilitate intervention before it is too late, our device measures peripheral perfusion and allows clinicians to prescribe preventative measures before an ulcer forms.


Pressure ulcers


Immobile patients suffer from constant pressure on specific areas, resulting in ulcers that often cause pain and are difficult to heal. Pressure ulcers (or decubitus ulcers) are a persistent and expensive problem in hospitals, nursing care homes, and long-term care facilities. Modulim’s technology can help detect these ulcers before they develop, so caregivers can intervene. If an ulcer has already formed, our technology can help clinicians track and document the impact of treatment attempts.

Reconstructive surgical flaps


Proper perfusion is critical for successful reconstructive flap procedures following mastectomies or other surgeries with pedicle flaps or free tissue transfer flaps. Although there are other ways to measure perfusion, the current standard of care relies on subjective evaluation of tissue discoloration and temperature. We measure surface and subsurface tissue components (hemoglobin and tissue oxygenation) to visualize the distribution of perfusion without the use of contrast agents. Our technology enables pre-operative planning, intra-operative validation of successful attachment, and post-operative monitoring (e.g., Gioux et al., 2011).



The correct treatment of burns depends entirely on an accurate diagnosis of a wound’s severity. Unfortunately, even experts incorrectly diagnose partial thickness burns a third of the time (Mazhar et al., 2014). Current analysis is based on subjective evaluation of wound coloring, tissue necrosis, burn surface area, and edema.


Modulim’s technique can assess the structure and function of a burn quantitatively. Recent peer-reviewed studies have shown that our results correlate to current gold standard histology measurements of burn depth, without the pain of a biopsy (e.g., Mazhar et al., 2014).  Additionally, our measurements help distinguish burn severity prior to visible changes in the wound, which may help clinicians make treatment decisions earlier.