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Research Applications

Skin assessment

 

Because spatial frequency domain imaging (SFDI) can “see beyond” what the eye can see, we can capture a true assessment of underlying skin health. Many factors — melanin, epidermal thickness, collagen structure, hydration, and blood distribution — contribute to skin health and appearance. Our subsurface imaging allows us to quantify these components even before they are visible to help in skin assessment research.

 

We use structured illumination to take several snapshots with various patterns and colors, and then apply our advanced algorithms to combine these images and make it easy to understand the results. Our method measures a wide field of view and corrects for surface topology across all body areas, even the contours of a face (e.g., Balu et al., 2013; Gioux et al., 2009).

 

Pre-clinical research

 

SFDI technology can help address the timeliness and difficulty of measuring efficacy when developing new products or therapies. Determining the functionality of new treatments is often a challenge that requires time-intensive and invasive histological evaluation.

 

Modulim’s technique can minimize this burden by localizing contrast over an area 100x larger than histology. Because the measurement is noninvasive, longitudinal monitoring can be conducted with the same animal, instead of groups. And with real-time results, SFDI is able to measure acute dynamics effectively.

Basic research

 

Over the last ten years, SFDI has been increasingly adopted in a wide variety of fields and enabled research in application areas for both industry and academia. The results have been published internationally in peer-reviewed journals (e.g., Laughney et al., 2013; O’Sullivan et al., 2012; Cuccia et al., 2009).

 

Reflect RS® for research

 

Modulim’s research system — Reflect RS® — is a user-friendly, non-contact imaging device for biomedical researchers to detect and visualize spatially resolved optical and functional parameters of biological tissue. Like our Clarifi™ system, it is designed to balance standardization and flexibility, so we can meet the diverse needs of our customers.

 

Reflect RS® is a turnkey hardware and software solution for researchers who need to image optical properties (µa and µs) of tissue or any scattering sample over large fields of view, so you can:

 

  • Detect remitted light and analyze data using our proprietary algorithms to isolate optical properties
  • Visualize lateral spatial distribution of tissue chromophores over a contoured surface
  • Quantify multispectral diffuse reflectance and derived optical properties for longitudinal monitoring and inter-sample comparison

 

Modulim’s software can be customized and easily configured by the user, including user-defined custom pattern illumination.

 

Our flexible products enable custom wavelength, spatial frequency, and field-of-view imaging to fit your specific needs. We make hardware and software that gives you the tools to acquire, analyze, and visualize your SFDI data, to save time so you can immediately address your research interests.