Clarifi makes microvascular assessment simple.

Clarifi Imaging System is the first non-contact, noninvasive microvascular assessment tool that uses a proprietary optical imaging technique — spatial frequency domain imaging (SFDI) — to measure tissue oxygenation and perfusion at the point-of-care in seconds.

Measure what matters!

Clarifi quantifies and maps five hemoglobin biomarkers of oxygenation and perfusion. These biomarkers help clinicians identify problems, manage patients, and personalize treatment to reduce ulcers and amputations.


Limb Assessment, Management, & Preservation solution seamlessly fits into your existing workflow
  • Assess patients at the point-of-care using advanced microvascular imaging with Clarifi®.
  • Manage patient care efficiently between caregivers with the ability to store and share patient data securely with Modulim Cloud.
  • Preserve patient’s limbs with coordinated multidisciplinary care.

Modulim Cloud

Our HIPAA compliant Modulim Cloud creates a scalable infrastructure to allow for easy access to imaging and provides a backbone for patient data insights.

Automatic secure storage, indexing, and archiving of patient data

Curated timelines of patient progress

HIPAA compliant

Magnifi Software

  • Tailored worklist shows you the data you need to see when you need to see it
  • Remotely disposition patient care and follow up
  • Share data with colleagues for care collaboration or second opinion

Data Insights - Patients

Innovative technology designed to aide clinicians in diagnostics, care coordination, and patient management

Data Insights – Population

Microvascular insights, data analytics, and clinical dashboards help clinicians guide care

Microvascular insights empower clinicians to manage patients with potential circulatory compromise

The clinician team can leverage Clarifi® Data Analytics to connect patients with multi-specialty care and help preserve limbs

Other Clinical Applications + Research

SFDI can help providers with clinical insights like these:

Diabetic foot ulcers & PAD

Poor peripheral circulation in diabetes patients accelerates silent vascular changes and can lead to a diabetic foot ulcer (DFU) and Peripheral Arterial Disease (PAD). The end result for the patient is often an amputation. DFUs are common (34% of diabetes patients get an ulcer in their lifetime), costly, and debilitating (Armstrong et al., 2017). Unfortunately, PAD is underdiagnosed due to a lack of noninvasive testing. To facilitate targeted intervention before an amputation is needed, our technology measures peripheral perfusion and allows clinicians to better manage their patients’ complications.

Recent publications show:

  • SFDI was used to identify unique signatures of compromised circulation in diabetes and PAD patients (Weinkauf et al., 2019).

  • SFDI was used to identify high risk patients in a larger population with the goal of risk stratification (Lee et al., 2020).

  • SFDI was used to differentiate the etiology (neuropathic vs. neuro-ischemic) of DFUs (Murphy et al., 2020).

  • SFDI Was used to stratify severity of microvascular disease (Jett et al., 2021).

  • SFDI was used to differentiate the etiology (neuropathic vs. neuro-ischemic) of DFUs (Murphy et al., 2020).

Pressure ulcers

Immobile patients suffer from constant pressure on specific areas, resulting in ulcers that often cause pain and are difficult to heal. Pressure ulcers (or decubitus ulcers) are persistent and costly problems in hospitals, nursinghomes, and long-term care facilities. The mitigation strategy often involves constant rotation of patients, which uses the time and resources of care providers. Modulim’s SFDI technology can help clinicians monitor circulation changes that precede ulcers and allow caregivers to intervene proactively. If an ulcer has already formed, SFDI technology can help clinicians track and document the impact of treatment attempts. A recent publication demonstrated how SFDI was used as a tool for skin assessment in subjects at risk for pressure ulcers (Yafi et al. 2017).

Reconstructive surgical flaps

Proper oxygenation and perfusion are critical for successful reconstructive flap procedures following mastectomies or other surgeries with pedicle flaps or free tissue transfer flaps. Although there are different ways to measure perfusion, the current standard of care relies on the subjective evaluation of tissue discoloration and temperature. SFDI provides clinicians a wide-field distribution of perfusion without the use of contrast agents. This information can enable clinicians to perform preoperative planning, intra-operative validation of successful attachment, and post-operative monitoring. A publication from 2013 showed SFDI being used for the assessment of flaps in mastectomy procedures (Gioux et al., 2013).


Treatment of burns depends on an accurate diagnosis of a wound’s severity. Unfortunately, even experts incorrectly diagnose partial thickness burns a third of the time because evaluation is based on visual inspection of wound coloring, tissue necrosis, burn surface area, and edema.

Modulim’s SFDI technology can assess the structure and function of tissue in burn areas quantitatively. Recent peer-reviewed studies have shown:

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